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Visually inspect OZEMPIC before use. It should appear clear and colorless. Do not use OZEMPIC if particles and discoloration are visible.
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Administer OZEMPIC once a week, every week on the same day, at any time of the day, with or without meals.
• Inject OZEMPIC subcutaneously into the abdomen, thigh or upper arm. Instruct patients to use a different injection site each week when injecting into the same region of the body.

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When using OZEMPIC with insulin, instruct patients to administer the products as separate injections and never mix the products. It is acceptable to inject OZEMPIC and insulin into the same region of the body, but the injections should not be next to each other.

Start OZEMPIC with a dosage of 0.25 mg injected subcutaneously once a week for 4 weeks. The dosage of 0.25 mg is intended for the initiation of treatment and is not effective for glycemic control.

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• After 4 weeks with the dosage of 0.25 mg, increase the dosage to 0.5 mg once weekly.

If additional glycemic control is required after at least 4 weeks at the 0.5 mg dosage, the dosage may be increased to 1 mg once weekly.
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If additional glycemic control is required after at least 4 weeks with the dosage of 1 mg, the dosage may be increased to 2 mg once weekly. The maximum recommended dose is 2 mg once weekly.

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The day of weekly administration can be changed if necessary, as long as the time between two doses is at least 2 days (>48 hours).
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If a dose is missed, administer OZEMPIC as soon as possible within 5 days of the missed dose. If more than 5 days have passed, skip the missed dose and administer the next dose on the regular day. In any case, patients will then be able to continue their regular, once-weekly dosing

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